Regulation of primary cilia by CILK1-mediated IFT protein phosphorylation

Project Identification
MUNI/IGA/1563/2020
Project Period
1/2021 - 12/2021
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine

Ciliogenesis associated kinase 1 (CILK1) is an evolutionary conserved regulator of cilia, but the molecular mechanism is not known. Using biochemical methods and in-cell experiments, we will identify motifs among the candidate proteins that are phosphorylated by CILK1, and determine functional consequences of this phosphorylation in cilia regulation. This will expand our understanding of basic cilia processes, and potentially contribute to management of yet untreatable CILK1-mediated disorders.

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