Molecular organization of the zygotic spindle apparatus in non-rodent embryos

Project Identification
Project Period
1/2022 - 12/2022
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine

Despite scientific advances in reproductive medicine, embryo development still holds a myriad of secrets. The reset of the cell cycle machinery driving the unification and segregation of two parental genomes in the fertilized egg is fundamental to all mammals. The proposed work will shed new light on basic cell cycle mechanisms underlying the transition from acentrosomal female meiosis to the first mitotic division in which sperm centrioles assume control of microtubule organization.


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