Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation

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Authors

KREJČÍ Pavel AKLIAN Anie KAUCKÁ Markéta ŠEVČÍKOVÁ Eva PROCHÁZKOVÁ Jiřina MIKOLKA Pavol BÁLEK Lukáš POSPÍŠILOVÁ Tereza SPOUSTOVÁ Tereza BRYJA Vítězslav VESELÁ Iva KOZUBÍK Alois WEIS MaryAnn PAZNEKAS W.A. WOLF J.H. GUTKIND J.S. WILCOX W.A. WNAG JABS E. SALAZAR Lisa MAŠEK Jan Kukla

Year of publication 2012
Type Article in Periodical
Magazine / Source Plos One
MU Faculty or unit

Faculty of Science

Citation
Doi http://dx.doi.org/10.1371/journal.pone.0035826
Field Physiology
Keywords Receptor tyrosin kinase; Wnt/beta catenin; MAPK; LRP6
Description Receptor tyrosine kinase signaling cooperates with WNT/beta catenin signaling in regulating many biological processes, but the mechanisms of their interaction remain poorly defined. We describe a potent activation of WNT/beta catenin by FGFR2 FGFR3, EGFR and TRKA kinases, which is independent of the PI3K/Akt pathway and it depends on ERK-MAPK mediated phospohrylation of WNT co-receptor LRP6.
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