Looking for inhibitor: structural and functional analysis of novel bangle lectin PHL from Photorhabdus asymbiotica

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This publication doesn't include Faculty of Medicine. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.

Authors	HOUSER Josef JANČAŘÍKOVÁ Gita DOBEŠ Pavel FUJDIAROVÁ Eva HYRŠL Pavel CSÁVÁS Magdolna MORAVCOVÁ Jitka WIMMEROVÁ Michaela
Year of publication	2018
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	In Photorhabdus asymbiotica genom, we identified a gene for a putative lectin, and examined the corresponding recombinant protein PHL from functional and structural point of view. We succeeded in determining structure of PHL in complex with several monosaccharides and tested a wide range of various mono-, di- and oligovalent carbohydrate-based molecules. Data gained so far show the way for design and synthesis of potential therapeutics.
Related projects:	Czech Infrastructure for Integrative Structural Biology Czech Infrastructure for Integrative Structural Biology for Human Health Lektiny a jejich úloha v interakci patogen/hostitel a buněčném rozpoznávání