Stanovení hladiny psychofarmak metodou suché krevní skvrny- proveditelné v reálné praxi?

Title in English Determination of psychoactive drugs in dried blood spots- is it feasible in clinical practice?


Year of publication 2021
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Description Advanced analytical methods today are very specific, sensitive and make it possible to determine substances in very low concentrations in various biological matrices. For a long time now, the application of these methods for determining the levels of drugs in dry blood spots has seemed attractive. However, the practical feasibility is limited by a number of factors (low sample volume (30-50 µl), matrix influence (hematocrit, hemoglobin, erythrocytes). Similarly, interpretation is hampered by the unclear relationship between capillary blood and plasma concentrations.
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