Stanovení hladiny psychofarmak metodou suché krevní skvrny- proveditelné v reálné praxi?
|Title in English||Determination of psychoactive drugs in dried blood spots- is it feasible in clinical practice?|
|Year of publication||2021|
|MU Faculty or unit|
|Description||Advanced analytical methods today are very specific, sensitive and make it possible to determine substances in very low concentrations in various biological matrices. For a long time now, the application of these methods for determining the levels of drugs in dry blood spots has seemed attractive. However, the practical feasibility is limited by a number of factors (low sample volume (30-50 µl), matrix influence (hematocrit, hemoglobin, erythrocytes). Similarly, interpretation is hampered by the unclear relationship between capillary blood and plasma concentrations.|