Hemodynamic and white blood cells parameters in patients with first-episode psychosis: a pilot longitudinal study

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This publication doesn't include Faculty of Medicine. It includes Faculty of Pharmacy. Official publication website can be found on muni.cz.

Authors

USTOHAL Libor MAYEROVÁ Michaela HORSKÁ Kateřina OBDRŽÁLKOVÁ Marie CRHOVÁ Hana PŘIKRYLOVÁ KUČEROVÁ Hana ČEŠKOVÁ Eva KAŠPÁREK Tomáš

Year of publication 2021
Type Article in Periodical
Magazine / Source International Journal of Psychiatry in Clinical Practice
MU Faculty or unit

Faculty of Pharmacy

Citation
Web https://www.scopus.com/record/display.uri?eid=2-s2.0-85112203308&origin=resultslist&sort=plf-f&src=s&st1=10.1080%2f13651501.2021.1962357&sid=f03bd77f6a040ba376eeade2bc9d5032&sot=b&sdt=b&sl=34&s=DOI%2810.1080%2f13651501.2021.1962357%29&relpos=0&citeCnt=0&
Doi http://dx.doi.org/10.1080/13651501.2021.1962357
Keywords First-episode psychosis; mean arterial pressure; monocyte-to-lymphocyte ratio; neutrophil-to-lymphocyte ratio; pulse pressure; rate pressure product
Description Objective Patients with schizophrenia are at higher risk of cardiovascular (CVS) related mortality. Close attention is being paid to the clinical utility of readily available CVS markers. Methods A pilot one-year longitudinal study in inpatients with first-episode psychosis (FEP) was carried out to determine markers of inflammation and endothelial dysfunction (monocyte- and neutrophil-to-lymphocyte ratios) and basal blood pressure, pulse, and derived hemodynamic parameters (PP: pulse pressure; RPP: rate pressure product; and MAP: mean arterial pressure). Results After one year, PP and RPP increased, as did systolic blood pressure and heart rate. Systolic blood pressure, PP, total white blood cells, and neutrophils correlated with weight gain. After one year, correlations between monocyte-to-lymphocyte ratio and RPP and MAP were observed. Conclusion Our study indicates worsening CVS health over the first year of treatment and emphasises the importance of early monitoring of CVS status using easily accessible parameters to prevent CVS-related mortality.

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