Langerhansova histiocytóza v dětském věku

Title in English Langerhans histiocytosis in children


Year of publication 2021
Type Article in Periodical
Magazine / Source Česko-slovenská pediatrie
MU Faculty or unit

Faculty of Medicine

Keywords Langerhans histiocytosis; myeloid neoplasm; BRAFV600E mutation; LCH-associated neurodegeneration of brain
Description Langerhans cell histiocytosis (LCH) is the most common of the histiocytic disorders and occurs when the body accumulates too many immature Langerhans cells, a subset of the larger family of cells known as histiocytes. Scientific discussions on the definition of LCH used to be debated in terms of its classification as either an immune dysfunction or a rare cancer (neoplastic and malignant or not malignant). According to most experts, Langerhans cell histiocytosis (LCH) is currently classified as a myeloid neoplasm.

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