Segregation of nucleolar components coicides with caspase-3 activation in cisplatin-treated HeLa cells
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Cell Science |
| MU Faculty or unit | |
| Citation | |
| Field | Morphological specializations and cytology |
| Description | We studied morphological changes of the nucleoli in HeLa cells traeted with cisplatin and compared them with induction of markers of programmed cell death and TUNEL staining. Remarkable segregation of nucleolar argyrophillic proteins, nucleolar RNA and a simultaneous activation of the cascade od caspases markedly preceded the TUNEL positivity in cisplatin-treated heLa cells. |
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