p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts

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Authors

NAVRÁTILOVÁ Jarmila HORVÁTH Viktor KOZUBÍK Alois LOJEK Antonín LIPSICK Joseph ŠMARDA Jan

Year of publication 2007
Type Article in Periodical
Magazine / Source Differentiation
MU Faculty or unit

Faculty of Science

Citation
Field Oncology and hematology
Keywords p53; differentiation; cell cycle; apoptosis; monoblast
Description The p53 protein can control cell cycle progression, programmed cell death and differentiation of many cell types. In this work, we expressed human p53 protein in v-Myb-transformed chicken monoblasts. We found that even this protein possessing only 53% amino acid homology to its avian counterpart can significantly alter morphology and physiology of these cells causing the G2-phase cell cycle arrest and early monocytic differentiation. Our results document that the species-specific differences of the p53 molecules, promoters/enhancers, and co-factors in avian and human cells do not interfere with differentiation- and cell cycle arrest promoting capabilites of the p53 tumor suppressor even in the presence of functional v-Myb oncoprotein. The p53-induced differentiation and cell cycle arrest of v-Myb-transformed monoblasts are not associated with apoptosis suggesting that the p53-driven pathways controling apoptosis and differentiation/proliferation are independent.
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