Protein p53 zastavuje proliferaci a indukuje diferenciaci v-myb transformovaných monoblastů

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Title in English p53 protein blocks proliferation and induces differentiation of v-myb-transformed monoblasts
Authors

NAVRÁTILOVÁ Jarmila HORVÁTH Viktor KOZUBÍK Alois LOJEK Antonín ŠMARDA Jan

Year of publication 2007
Type Article in Proceedings
Conference Chemické listy
MU Faculty or unit

Faculty of Science

Citation
Field Oncology and hematology
Keywords p53; differentiation; proliferation; cell cycle; apoptosis
Description We expressed human p53 in avian monoblasts BM2. We showed that in spite of low level of structural homology of human and avian p53 proteins (53%) the human protein is capable of performing at least some of its functions: it blocked proliferation at G2 phase of the cell cycle and induced differentiation to monocytes. In contrast, we did not proved apoptosis-inducing function of human o53 in avian cells. These results document that even significant inter-species differencies tolerate functions of important regulators involved in control of cellular proliferation and differentiation.
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