Akutní a opakovaná aplikace metamfetaminu ovlivňuje expresi genů pro kanabinoidní CB1 receptor a dopaminový D1 receptor v myším mezencefalu


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Title in English Acute and repeated administration of methamphetamine affects gene expression of cannabinoid CB1 receptor and dopamine D1 receptor in mouse mesencephalon


Year of publication 2008
Type Article in Proceedings
Conference Quo vadis, psychiatria?
MU Faculty or unit

Faculty of Arts

Field Pharmacology and pharmaceutical chemistry
Keywords behavioural sensitization; methamphetamine; cannabinoids; gene expression; mice
Description I the present study we confirmed again that repeated pre-treatment with psychostimulant methamphetamine can provoke development of behavioural sensitization to methamphetamine stimulatory effects. In addition, further results of our pilot experiment showed that methamphetamine administration can elicit changes in both CB1 mRNA expression and D1 mRNA expression. In other words, using real-time polymerase chain reaction (PCR) we registered changes on the genomic level at least in the midbrain neurons, both in animals after acute drug administration and sensitized animals, which support findings of other authors who describe a reciprocal crosstalk between cannabinoid and dopamine receptors.
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