Repeated exposure to methamphetamine and methanandamide changes relative expression of D1 receptor in mouse midbrain
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Year of publication | 2008 |
Type | Article in Periodical |
Magazine / Source | European Neuropsychopharmacology |
MU Faculty or unit | |
Citation | |
Field | Pharmacology and pharmaceutical chemistry |
Keywords | PCR; behavioural sensitization; methamphetamine; cannabinoids; D1 receptor; mesencephalon |
Description | The results of the behavioural investigation showed: a) significant stimulatory influence of methamphetamine after the acute administration, b) development of sensitization to methamphetamine after its repeated treatment, c) development of cross-sensitization to methamphetamine after repeated pre-treatment with CB1 receptor agonist methanandamide. Real-time PCR results showed increased D1 mRNA expression both in animals sensitized to methamphetamine and in animals cross-sensitized to methamphetamine (repeatedly pre-treated with methanandamide). |
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