Role homocysteinu a příbuzných thiolů v etiopatogenezi poruch lidské reprodukce

Title in English The role of homocysteine and related thiols in etiopathogenesis of human reproduction disorders


Year of publication 2011
Type Article in Periodical
Magazine / Source Praktická gynekologie
MU Faculty or unit

Faculty of Medicine

Field Gynaecology and obstetrics
Keywords homocysteine; glutathione; thiols; oxidative stress; infertility
Description Metabolism of homocysteine and related thiols plays an important role in many physiological processes in human reproductive tract. Its disturbances influence methylation reactions and are strongly associated with an increased risk of oxidative stress. Imbalance of overproduction of free radicals and effectivity of antioxidation systems in germ cells is considered to be the fundamental factor of cell membrane and DNA injuries. Hyperhomocysteinemia inhibits the methylation reactions which play an important role in DNA repairs and genom stabilisation. The aim of the study is to introduce the overview of current knowledge about association of metabolism of homocysteine and related thiols and human reproduction.
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