Interleukin-1 Gene Polymorphisms Associated with Reflux Oesophagitis in the Czech Population



Year of publication 2011
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Description Reflux Oesophagitis (RO) is the subset of gastro-oesophageal reflux disease (GORD) with inflammation of the lower oesophagus due to acid gastric contents regurgitation. Polymorphisms in the interleukin-1 (IL-1) genes play a role in inflammatory diseases though the modulation of cytokine levels. The aim of this study was to associate the three variants in the IL-1 cluster with RO in the Czech population. In this case-control association study 131 patients with RO and 165 controls were genotyped using PCR-RFLP or PCR method for IL-1 gene polymorphisms [IL-1alpha (-889C/T), IL-1beta (+3953C/T), and IL-1RN (IL-1 receptor antagonist, VNTR)]. No significant differences were found in the allele and genotype frequencies of all polymorphisms between patients with RO and controls. Complex analysis revealed differences in IL-1 haplotype frequencies; the haplotype C(IL-1alpha-889)/C(IL-1beta+3953)/1(IL-1RN*1 allele) of the IL-1 gene cluster was significantly more frequent (54.8% vs. 43.7%, p=0.023) and the haplotype C(IL-1alpha-889)/C(IL-1beta+3953)/2(IL-1RN*2 allele) less frequent (11.9% vs. 21.2%, p=0.020) in RO patients than in controls. Although no significant role of single IL-1 variants in RO was found, our results suggest that different IL-1 haplotypes may be associated with increased or decreased susceptibility to RO. This study was supported by the project NPVII 2B06060, 1M0528 and IGA NT11405-6.
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