Současné přístupy k prevenci a léčbě nevolnosti a zvracení při chemoterapii
| Title in English | Current approaches to prevention and treatment of nausea and vomiting during chemotherapy |
|---|---|
| Authors | |
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Farmakoterapie |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | nausea and vomiting; chemotherapy; aprepitant; palonosetron |
| Description | The advent of 5-HT3 receptor inhibitors two decades ago became an important contribution to antiemetic prophylaxis but led to false idea that the problem of nausea and vomiting after chemotherapy has been solved. Despite of elaborated international guidelines for antiemesis significant reserve continues to apply them in clinical practice. Underestimation of real nausea and vomiting occurrence and their impact on patients are among reasons. Advantages of 5-HT3 receptor inhibitors combined with dexamethasone have not been fully employed despite of available convincing evidence. New antiemetics, especially palonosetron and aprepitant, further extend our potential of effective therapy, but it is necessary to use them in prophylaxis from the first course of emetogenic anticancer treatment according to guidelines. |