Vyšetření sérové koncentrace prealbuminu a selenu ke sledování nutričního stavu pacientů s fenylketonurií a hyperfenylalaninemií
| Title in English | Determination of prealbumin and selenium in serum for monitoring the nutrition status of phenylketonuric and hyperphenylalaninemic patients |
|---|---|
| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Čs. pediatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Paediatry |
| Keywords | hyperphenylalaninemia phenylketonuria pre-albumin selenium |
| Description | The objective of the present study was to assess the compliance of our phenylketonuric (PKU) and hyperphenylalaninemic (HPA) patients; to determine the concentration of serum pre-albumin and selenium to discover the potential correlation between the amount of proteins in food and their metabolic control. Material and Methods: The experimental group contained altogether 174 patients treated at the Department of Pediatrics of Medical Faculty of Masaryk University and University Hospital in Brno, of which 113 were children (age 1-18), 60 with PKU and 53 with HPA and 61 were adults (age 18- 42), 51 with PKU and 10 with HPA. All PKU patients given a low-protein diet took AAM. HPA patients given a low-protein diet were divided into two groups; in the first group AAM was prescribed and in the other it was not. Results: We did not prove a statistically significant difference in the concentration of serum pre-albumin among the respective groups. We approved statistically significant difference in serum selenium concentrations of adult PKU and HPA patients (p=0.006; Mann-Whitney U test). Conclusion: The preparation of therapeutic restrictive diet for PKU and HPA patients is very difficult, and can cause nutritional deficiency. Patients’ adherence to the diet is not always good. To attend to adherence of the therapeutic restrictive diet and search new ways of treatment and monitoring of the nutrition status of phenylketonuric and hyperphenylalaninemic patients at the same time is necessarily. |