Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients
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| Year of publication | 2012 |
| Type | Conference abstract |
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| Description | Aim: Phenylketonuria is an inherited disorder of metabolism of the amino acid phenylalanine caused by a deficit of the enzyme phenylalaninhydroxylase. It is treated with a low-protein diet containing a low content of phenylalanine to prevent mental affection of the patient. The objective of the present study was to assess the compliance of our phenylketonuric (PKU) and hyperphenylalaninemic (HPA) patients; to determine the concentration of serum pre-albumin, selenium, zinc and iron to discover the potential correlation between the amount of proteins in food and their metabolic control. Methods: We studied 174 patients of which 113 were children (age 1-18), 60 with PKU and 53 with HPA and 61 were adults (age 18-42), 51 with PKU and 10 with HPA. Results: We did not prove a statistically significant difference in the concentration of serum pre-albumin, zinc and iron among the respective groups. We approved statistically significant difference in serum selenium concentrations of adult PKU and HPA patients (p=0.006; Mann-Whitney U test). Conclusions: The concentration of serum selenium could be used as indirect marker in evaluation of the risk of late complications of dietary therapy. |