Immunoregulatory T cells in multiple sclerosis and the effect of interferon beta and glatiramer acetate treatment on T cell subpopulations

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Authors	PRAKSOVÁ Petra ŠTOURAČ Pavel BEDNAŘÍK Josef VLČKOVÁ Eva MIKULKOVÁ Zuzana MICHÁLEK Jaroslav
Year of publication	2012
Type	Article in Periodical
Magazine / Source	Journal of the Neurological Sciences
MU Faculty or unit	Central European Institute of Technology
Citation
Web	Full Text
Doi	http://dx.doi.org/10.1016/j.jns.2012.05.036
Field	Neurology, neurosurgery, neurosciences
Keywords	central memory T cells; glatiramer acetate; interferon beta; multiple sclerosis; naive T cells; regulatory T cells
Description	The objective of this study was to evaluate T cells subpopulations among multiple sclerosis patients. We analyzed lymphocyte subpopulations in MS patients and healthy controls and studied the treatment effects of interferon beta and glatiramer acetate treatment on T cells subpopulations during first year of treatment in comparison with untreated patients. We observed a significant increase of effector T cells and decrease in regulatory T cells in MS patients compared to healthy controls. After glatiramer acetate and interferon beta therapy we observed a significant decrease in effector T cells and thus the restoration of imbalance in the immune system.