The Association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute Heart Failure and Left Ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention

Authors

PÁVKOVÁ GOLDBERGOVÁ Monika PAŘENICA Jiří JARKOVSKÝ Jiří KALA Petr POLOCZEK Martin MAŇOUŠEK Jan KLUZ Krystyna KUBKOVÁ Lenka LITTNEROVÁ Simona TESÁK Martin TOMAN Ondřej PÁVEK Nikolas ČERMÁKOVÁ Zdeňka TOMANDL Josef VAŠKŮ Anna ŠPINAR Jindřich

Year of publication 2012
Type Article in Periodical
Magazine / Source Genetic Testing and Molecular Biomarkers
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1089/gtmb.2012.0120
Field Genetics and molecular biology
Keywords PROGNOSIS
Attached files
Description Tissue inhibitors of metalloproteinase (TIMPs) bind to active matrix metalloproteinase (MMPs), and thereby inhibit their proteolytic activity. We investigated the role of polymorphisms in the gene for TIMP-1 and serum levels of TIMP-1 in association with postmyocardial infarction (MI), left ventricular (LV) dysfunction, and symptoms of acute heart failure (AHF) in patients treated with primary percutaneous coronary intervention. Methods: In total, 556 patients with STEMI were evaluated. Levels of TIMP-1 were measured at admission and 24h after MI onset. The TIMP-1 exon 5 SNP rs4898 (F124F with T>C) located at X chromosome was assayed. Results: TIMP-1 levels were higher for men with AHF as well as for men with LV dysfunction (ejection fraction [EF]<40%). According to multivariate analysis, the TIMP-1 level was a factor with an independent negative relationship to EF and AHF in men. An independent relationship between exon 5 TIMP-1 gene polymorphism and EF, AHF or TIMP-1 level was not documented. Conclusion: These results provide evidence that a higher level of circulating TIMP-1 is independently associated with worse EF and AHF.
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