Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Neuroimmunology |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.sciencedirect.com/science/article/pii/S0165572812003177 |
| Doi | http://dx.doi.org/10.1016/j.jneuroim.2012.10.014 |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | Gene; HLA-DRB1*1501; Multiple sclerosis; Tagging polymorphism |
| Attached files | |
| Description | We investigated the HLA-DRB1*1501 tagging rs3135388 gene polymorphism and its association with multiple sclerosis (MS) susceptibility, disability and gender differences. The study group consisted of 306 MS patients and 137 healthy individuals. A significant difference in genotype distribution (Pg = 3.06 x 10 - 9) and allele frequency (Pa = 6.08 x 10- 10) between MS patients and controls was demonstrated. The homozygotes AA and heterozygotes GA were more frequent in MS patients (OR = 4.27, 95% CI: 2.64-6.92). A significant difference between female MS patients and female controls in genotype distribution (Pg = 1.3 x 10- 8) and allele frequency (Pa = 2.82 x 10- 9); (OR = 5.11, 95% CI: 2.86-9.15) was also proved. Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population. |
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