VLIV DLOUHODOBÉ APLIKACE HALOPERIDOLU NA ELEKTROGRAM IZOLOVANÉHO SRDCE A EXPRESI SIGMA 1 A IP3 RECEPTORŮ U MORČETE
| Title in English | EFFECT OF LONG-TERM APPLICATION OF HALOPERIDOL ON ELECTROGRAM OF ISOLATED HEART AND EXPRESSION OF SIGMA 1 AND IP3 RECEPTORS IN GUINEA PIG |
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| Authors | |
| Year of publication | 2012 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Our work was focused on effect of long-term application of haloperidol on electrogram of isolated heart and expression of sigma 1 and IP3 receptors in guinea pig. We showed that expression of sigma 1 receptors was increased in atria of the heart after long-term application of haloperidol. Withal, the spontaneous heart rate was decreased, the QT interval of electrogram was extended and incidence of supraventricular extrasystoles was increased. |
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