Získaná hemofile A s těžkým průběhem – kazuistika
| Title in English | A severe course of acquired haemophilia A – case report |
|---|---|
| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Anesteziologie a intenzivní medicína |
| MU Faculty or unit | |
| Citation | |
| Field | Other specializations of internal medicine |
| Keywords | case report; coagulation; circulating anticoagulant; factor VIII inhibitor |
| Description | Circulating anticoagulants are endogenous substances interfering in the coagulation cascade, which may even lead to severe bleeding. In the vast majority of cases, these substances are immunoglobulins, production of which may be induced by the administration of coagulation factor concentrates, e. g. in haemophilia patients. However, they can also be associated with malignant neoplasms, drug interactions and old age. The authors present a case report of an 84-years-old female patient in whom factor VII inhibitor was detected following urological surgery. Although diagnostic tests for anticoagulants were negative prior to surgery, the patient developed coagulation inhibitors afterwards – most probably due to numerous blood transfusions. The patient died on the 5th day in spite of early detection of anticoagulant production and subsequent complex therapy. |