Prostatický specifický antigen, metalothionein a caveolin-1 jako markery vzniku a rozvoje karcinomu prostaty
| Title in English | Prostate Specific Antigen, Metallothionein and Caveolin-1 as Markers of Formation and Development of Prostate Carcinom |
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| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Chemické listy |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.chemicke-listy.cz/docs/full/2012_11_1075-1080.pdf |
| Doi | http://dx.doi.org/10.1039/c2ib00157h |
| Field | Biochemistry |
| Keywords | prostate cancer;metallothionein;prostatic specific antigen;caveolin-1 |
| Description | The current diagnostic limitations of prostate cancer have shown that the development of new approaches to early detection of aggressive forms of of the cancer is very important. A comprehensive approach to detection of potential tumour markers using different methods and their optimization is described. We focused on caveolin-1 and metallothionein and the obtained results were compared with prostate specific antigen as a golden standard of prostate cancer markers. All the mentioned markers were detected on both the mRNA and protein levels in three types of prostate cell lines. Metallothionein and caveolin-1 rank among the promising markers in prostate cancer diagnosis, especially. for distinguishing aggressive silent forms of the disease. |