POKROKY V SYSTÉMOVÉ LÉČBĚ KOSTNÍCH SARKOMŮ
| Title in English | ADVANCES IN SYSTEMIC TREATMENT OF BONE SARCOMAS |
|---|---|
| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Ortopedie |
| MU Faculty or unit | |
| Citation | |
| Web | http://medakta.cz/cislo.php?casopis=ortopedie&rocnik=2012&cislo=2#495 |
| Field | Oncology and hematology |
| Keywords | bone sarcoma; targeted therapy; angiogenesis; protein kinase inhibitors |
| Description | At present, the therapeutic success in the treatment of bone sarcoma is significantly higher compared to historical cohorts with 60-70% overall survival. Unfortunately, no progress in better survival of patients with relapsing and refractory bone sarcomas has been observed during the last twenty years. This article provides a summary description of investigated targeted-therapy methods applied in the treatment of bone sarcomas that may give patients suffering from relapsing and chemoresistant bone sarcomas a better chance of survival. The majority of the targeted drugs are being administered within the scope of phase 1 or 2 studies. |