The fibroblast growth factors in multiple myeloma

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Authors	KREJČÍ Pavel MEKIKIAN PB WILCOX WR
Year of publication	2006
Type	Article in Periodical
Magazine / Source	Leukemia
MU Faculty or unit	Faculty of Science
Citation
Web	fulltext
Doi	http://dx.doi.org/10.1038/sj.leu.2404202
Field	Physiology
Keywords	FACTOR RECEPTOR-3; EXPRESSION; MUTATIONS
Description	Fibroblast growth factor receptor 3 (FGFR3) is a membrane-anchored receptor tyrosine kinase that transmits intercellular signals mediated by a family of fibroblast growth factors (FGFs). In multiple myeloma (MM), 15% of patients markedly upregulate FGFR3 as a consequence of a t(4;14)(p16.3;q32) translocation. Ectopic expression of FGFR3 enhances MM cell proliferation and survival, demonstrating the oncogenic potential of FGFR3.