Časná poporodní konverze gestačního diabetes mellitus do permanentního diabetu či prediabetu v České republice: epidemiologická studie

Title in English Early post-partum conversion of gestational diabetes mellitus to permanent diabetes mellitus or prediabetes in Czech Republic: an epidemiological study


Year of publication 2013
Type Article in Periodical
Magazine / Source Diabetologie - Metabolismus - Endokrinologie - Výživa : časopis pro postgraduální vzdělávání
MU Faculty or unit

Faculty of Medicine

Web http://www.tigis.cz/images/stories/DMEV/2013/01/02_bartakova_dmev_1-13.pdf
Field Physiology
Keywords Gestational diabetes mellitus pregnancy oGTT test HbA1c AUC post partum diabetes
Description Incidence of type 1 and 2 as well as gestational diabetes mellitus (GDM) are increasing worldwide including Czech Republic. Given that women with previous GDM have a higher risk of diabetes development later in life compared to women with a physiological pregnancy, the aims of our study were (1) to ascertain a frequency of early postpartum conversion of GDM into permanent diabetes or prediabetes and (2) to find an eventual significant predictive factors from those routinely measured during the GDM follow up. We carried out a retrospective epidemiological analysis of anamnestic, anthropometric, biochemical and clinical data of female patients from The Diabetology Centre of Faculty Hospital Brno Bohunice with GDM diagnosis during the 2005 – 2011 period that underwent repeated oGTT up to 1 year after delivery were included in this analysis (n = 1090 representing approx.. half of all patients with GDM followed-up in the centre during the given time period). Any degree of impairment of glucose tolerance postpartum was detected in 11.7% subjects, of those manifest DM had 4.1% (2.8% T2DM and 1.3% T1DM). Glycaemia in all three time-points of oGTT and HbA1c were significantly associated with the postpartum abnormality. More exact risk estimation o GDM conversion based on glucose metabolism parameters ascertained during gravidity could help to stratify GDM subjects according to future risks and to establish more effective screening of postpartum impaired glucose tolerance.
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