Brain-derived neurotrophic factor and ciliary neurotrophic factor in maternal plasma and umbilical cord blood from pre-eclamptic and physiological pregnancies

Authors

BIENERTOVÁ VAŠKŮ Julie BIENERT Petr ZLÁMAL Filip ŠPLÍCHAL Zbyněk TOMANDL Josef TOMANDLOVÁ Marie HODICKÁ Zuzana VENTRUBA Pavel VAŠKŮ Anna

Year of publication 2013
Type Article in Periodical
Magazine / Source JOURNAL OF OBSTETRICS AND GYNAECOLOGY
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.3109/01443615.2013.776026
Field Gynaecology and obstetrics
Keywords Brain-derived neurotrophic factor; ciliary neurotrophic factor; pre-eclampsia
Attached files
Description The aim of the study was to investigate the circulating levels of ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) in maternal serum and umbilical cord blood from respective pregnancies in pre-eclampsia (PE) cases and a control cohort. A total of 12 pre-eclampsia cases and 34 healthy controls were enrolled and the maternal peripheral blood - umbilical cord blood duos, were examined for BDNF and CNTF levels. BNDF levels were significantly higher in umbilical cord blood from pre-eclamptic pregnancies; there was also significant difference between maternal plasma and umbilical cord blood levels of BDNF (p < 0.001) in the controls. The CNTF levels in umbilical cord blood (CNTF-UCB) were significantly higher in PE cases than in the controls (p = 0.03). Significant differences were observed in expression of BDNF and CNTF proteins in maternal peripheral blood and umbilical cord blood between pre-eclampsia cases and healthy controls.

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