Možnosti studia transendoteliální migrace in vitro


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Title in English Techniques to Study Transendothelial Migration In Vitro


Year of publication 2014
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Science

Field Genetics and molecular biology
Keywords transendothelial migration; extravasation; endothelial cells; metastasis; transwell system
Description The most dangerous aspect of cancer is the metastatic spread to other parts of the body. Cancer cells frequently use circulation to spread to secondary locations. By entering the bloodstream (in a process called intravasation) and by crossing the vessel walls at the metastatic sites (extravasation) tumor cells disseminate to distal organs and eventually form life-threatening metastases. Crossing the vessel walls (transendothelial migration) is a vital step of metastatic cascade. There are several methods to study transendothelial migration in living models. Although they offer complex physiological microenvironment, they are expensive and technically demanding, therefore not widely used. As an alternative, sophisticated techniques to investigate transendothelial migration in vitro have been developed. Classification, modifications, pros and cons of the in vitro techniques for studying transendothelial migration are summarized in this review.

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