Prognostic significance of selected biomarkers in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease
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| Year of publication | 2014 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein" 16 (CC16), S100 protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IPF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n = 51)), and in 155 healthy controls. Biomarkers were measured at diagnosis and compared with disease characteristics. Six significant correlations were found: 1) BALF TFF3 level was associated with HRCT interstitial •score in IPF (P=0.052); 2) BALF PSP94 level with prognosis of sarcoidosis (P=0.035); 3) BALF SP-A level with pulmonary functions in IPF (P=0.032); 4) BALF SP-D and TT3 with IPF mortality (P=0.049 and 0.017, respectively); 5) serum TT3 level with COPD mortality (P=0.006,); and 6) serum SP-A was with pulmonary functions impairment in IPF (P=0.011). Moreover, our analysis showed that some biomarker levels have differed significantly among the diseases: 1) BALF SP-D level differed between sarcoidosis and IPF; 2) serum SP-A and S100 differed among IPF, sarcoidosis and COPD; 3) serum SP-D and TFF3 distinguished IPF and COPD patients from healthy controls; and 4) serum PSP94 distinguished COPD patients from healthy controls. Our study shows that some of selected biomarkers should have prognostic value in analyzed lung disorders. On the other hand these biomarkers do not appear to be unequivocally suitable for differential diagnosis of these disorders. |