Cirkulující a extracelulární mikroRNA jako nové potenciální diagnostické markery pro gynekologické malignity
| Title in English | Circulating and extracellular microRNAs as new diagnostic biomarkers for gynecological cancers |
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| Authors | |
| Year of publication | 2014 |
| Type | Article in Periodical |
| Magazine / Source | Praktická gynekologie |
| MU Faculty or unit | |
| Citation | |
| Field | Gynaecology and obstetrics |
| Keywords | diagnosis; cervical cancer; endometrial cancer; ovarian cancer; blood; microRNA; urine; plasma; serum |
| Description | Small, non-coding molecules of RNA, microRNAs, have been shown to participate in regulation of key biological processes in the cells. They regulate the expression at post-transcriptional level by binding to target mRNA, resulting in mRNA degradation or translation inhibition. The most recent investigations revealed that microRNAs may occur not only in the cells, but also in many body fluids. Differential expression of particular microRNAs is often associated with many pathological states. Therefore, the detection of deregulated microRNAs in diagnostically relevant samples such as blood, plasma/serum, or urine may become the basis for the establishment of novel diagnostic procedures. Finding alternative diagnostic biomarkers for gynecological cancers is the goal of many recent investigations. We present here the survey of novel circulating and extracellular microRNAs which have been found deregulated in ovarian cancer, endometrial cancer and cervical cancer, particularly in blood, plasma/serum and urine samples. |