Patofyziológia vzniku motorických nežiaducich účinkov dlhodobej dopaminergnej liečby Parkinsonovej choroby

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Title in English	Patophysiology of motor adverse event of long term treatment of Parkinson’s disease with dopaminergic medication
Authors	VESELÝ Branislav HAJAŠ Gabriel BROZMAN Miroslav REKTOR Ivan
Year of publication	2015
Type	Article in Periodical
Magazine / Source	Neurologie pro praxi
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.neurologiapreprax.sk/index.php?page=magazine_detail&issue_id=657
Field	Neurology, neurosurgery, neurosciences
Keywords	dyskinesias; motor fluctuation; priming; pulsative stimulation dopamine denervation; pharmacokinetics of levodopa
Attached files	ZVV_2015_112_1315632_Patofyziologia_vzniku.pdf
Description	Treatment of Parkinson’s disease with dopaminergic preparation has besides the positive effects on the course of the disease many side effects. The most prominent adverse event of long term administration of levodopa and dopamine receptor agonist are motor fluctuation, levodopa induced dyskinesias and psychotic side effects. Authors in the article describe the patophysiology of motor fluctuation and levodopa induced dyskinesias in the patients with Parkinson’s disease treated by dopaminergic medication.