Chronobiology of acute cardiovascular events.
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| Year of publication | 2015 |
| Type | Conference abstract |
| Citation | |
| Description | Incidence of acute cardiovascular diseases show chronobiological variations, althought little is known about its influence on further prognosis and mortality. Circadian rhythms are genetically determined and variations at the molecular level can modulate the response to external/internal stumuli affecting thus fenotype of the disease. In our research we investigated circadian pattern of time of onset in acute myocardial infarction and acute heart failure and its influence on clinical parametres of the disease. Further we focues on effect of chronotype (determined by functional polymorphism VNTR in Period3 gene) on basic parametres of myocardial infarction. Rhythmicity of clinical data and biochemical factors was investigated by using partial Fourier analysis and patients with AMI were genotyped for Per3 VNTR polymorphism using an allele-specific PCR. |