Use of micro computed-tomography and 3D printing for reverse engineering of mouse embryo nasal capsule

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Year of publication 2016
Type Article in Periodical
Magazine / Source Journal of Instrumentation
MU Faculty or unit

Faculty of Medicine

Field Genetics and molecular biology
Keywords Computerized Tomography (CT) and Computed Radiography (CR); Image reconstruction in medical imaging; Multi-modality systems
Description Imaging of increasingly complex cartilage in vertebrate embryos is one of the key tasks of developmental biology. This is especially important to study shape-organizing processes during initial skeletal formation and growth. Advanced imaging techniques that are reflecting biological needs give a powerful impulse to push the boundaries of biological visualization. Recently, techniques for contrasting tissues and organs have improved considerably, extending traditional 2D imaging approaches to 3D. X-ray micro computed tomography (mu CT), which allows 3D imaging of biological objects including their internal structures with a resolution in the micrometer range, in combination with contrasting techniques seems to be the most suitable approach for non-destructive imaging of embryonic developing cartilage. Despite there are many software-based ways for visualization of 3D data sets, having a real solid model of the studied object might give novel opportunities to fully understand the shape-organizing processes in the developing body. In this feasibility study we demonstrated the full procedure of creating a real 3D object of mouse embryo nasal capsule, i.e. the staining, the mu CT scanning combined by the advanced data processing and the 3D printing.
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