Neuromuskulární symptomatologie jako první projev maligního onemocnění a původní evoluční význam změn chování, vyvolaných prozánětlivými cytokiny
| Title in English | Neuromuscular symtopatology as primary manifestation of a malignant neoplasm and a phylogenetic importance of behaviour changes induced by pro inflammatory cytokines |
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| Authors | |
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Onkologie |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | paraneoplastic symptom; sickness behaviour; pro-inflammatory cytokine; myalgia; insomnia; depression |
| Description | Pro-inflammatory cytokines and hormonal changes in oncological diseases induce metabolic, neurological and psychic changes which could be presented as first symptoms of an occult malignant tumour. Moreover, the production of several types of auto-antibodies could make symptoms similar to autoimmune diseases. Specific behaviour changes due to pro-inflammatory signals from the periphery are characteristic for all mammals and have their own phylogenetic importance, which have been developed with wounded and sick animals in order to redistribute their energy resources to facilitate healing wounds and infections on the one hand, and to induce hyper-vigilance against a future predator attack on the other hand. |