Aktuální onkologická léčba high-grade gliomů
| Title in English | Current strategy for treatment of high-grade gliomas |
|---|---|
| Authors | |
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Neurologie pro praxi |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | high-grade glioma; glioblastoma; radiotherapy; chemotherapy; prognostic factors; molecular biomarkers |
| Description | In recent decades, there have been significant advances in the standard therapy of high-grade gliomas. New surgical procedures were introduced; radiotherapy methods were improved. It was also found that the use of chemotherapy in specific tumor types further improves the treatment effects. Diagnostic procedures developed as well. However, treatment results are still not satisfactory. The survival of patients with glioblastoma improved only by a few months in the last several decades. The mainstay of malignant gliomas treatment is always maximal safe tumor resection as feasible without functional consequences. Additional treatment depends on histology but also prognostic and predictive factors. The main traditional prognostic factors include age, performance status and the extent of resection. Novel prognostic factors are cytogenetic and molecular biomarkers, some of which may also predict response to the treatment. |