Fekální bakterioterapie v léčbě klostridiové kolitidy

Title in English Fecal bacteriotherapy in the treatment of Clostridium difficile infection


Year of publication 2018
Type Article in Periodical
Magazine / Source Epidemiologie, mikrobiologie, imunologie
MU Faculty or unit

Faculty of Medicine

Keywords fecal bacteriotherapy; recurrent Clostridium difficile colitis; intestinal microbiome
Description Aim of the thesis: Using a prospective analysis to assess a success of faecal bacteriotherapy in the colitis due to Clostridium difficile therapy. To analyze whether any of the factors according to which the treated patients can be classified, has a statistically significant influence on a treatment assessment from a point of view of its success. Materials and methods: The method was applied to 71 patients during the 2-year study period (2015–2016). After treatment, the patients were followed up by means of personal visits or by phone. If colitis did not recur within eight weeks, the treatment was considered successful. Results: Overall success rate was 76%, with statistically insignificant decline in recurrences. Subgroup analysis did not show any statistically significant difference in success rate between administration via nasoenteral feeding tube and rectal enema. Likewise, there were no statistically significant differences due to prior antibiotic therapy type, nor between the use of fresh and cryo-stored stool suspension. No unexpected adverse events or lethality occurred in the study period. Conclusions: Fecal bacteriotherapy is a successful and safety therapeutic alternative for recurrent C. difficile infections.

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