The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

Authors	SAMEC Marek LISKOVA Alena KUBATKA Peter URAMOVA Sona ZUBOR Pavol SAMUEL Samson Mathews ZULLI Anthony PEC Martin BIELIK Tibor BIRINGER Kamil KUDELA Erik BENACKA Jozef ADAMEK Mariusz RODRIGO Luis CICCOCIOPPO Rachele KWON Taeg Kyu BARANENKO Denis KRUŽLIAK Peter BUSSELBERG Daniel
Year of publication	2019
Type	Article in Periodical
Magazine / Source	Journal of cancer research and clinical oncology
MU Faculty or unit	Faculty of Medicine
Citation
Web	http://dx.doi.org/10.1007/s00432-019-02940-0
Doi	http://dx.doi.org/10.1007/s00432-019-02940-0
Keywords	microRNAs; Phytochemicals; Plant-derived food; Cancer; Carcinogenesis
Description	PurposePhytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis.ResultsThis comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research.ConclusionsSignificant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.