Vliv abúzu psychoaktivních látek na průběh a funkční schopnosti u pacientů se schizofrenií
| Title in English | AN IMPACT OF PSYCHOACTIVE SUBSTANCE ABUSE ON A COURSE AND FUNCTIONAL ABILITIES IN PATIENTS WITH SCHIZOPHRENIA |
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| Authors | |
| Year of publication | 2019 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.cspsychiatr.cz/detail.php?stat=1244 |
| Keywords | residual symptoms; schizophrenia; social adjustment; substance-related disorders; treatment outcome |
| Attached files | |
| Description | Introduction: Psychoactive substance abuse is a well-known adverse factor in patients with schizophrenia. It influences a compliance, relapse rate and social adaptation. Furthermore it is more common if compared to a healthy population and it is influenceable and so it is a possible target for the treatment interventions. Method: We conducted a crossover study in patients with schizophrenia that were treated in outpatient department of the Department of Psychiatry of the University Hospital in Ostrava. The course of the disorder was evaluated as the frequency of relapse, measured by the average number of hospitalizations per year. The indicators of social adaptation (housing, employment/study, relationship) and functional abilities (PSP scale) were followed. The presence of the residual symptoms (positive, negative, affective) was observed. Results: Alltogether 102 patients were included to the evaluation. In one third of them the psychoactive substance abuse or dependence occured. The relapse rate per year was significantly higher in a combination of amphetamines and cannabinoids if compared to other psychoactive substances or their combinations or the abstainers. We didn´t find any significant differences in any other of the followed variables. Conclusion: The study has proven the adverse impact of the abuse of cannabinoids and amphetamines on the course of schizophrenia, measured by the average relapse rate per year. We didn't proven the negative impact on social and functional abilities of the patients that is otherwise well-known. The problem of dual diagnosis requires the development and support of specialized intervention programs. |