Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC)

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This publication doesn't include Faculty of Medicine. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.
Authors

IRIMIE-AGHIORGHIESEI Alexandra Iulia POP-BICA Cecilia PINTEA Sebastian BRAICU Cornelia COJOCNEANU Roxana ZIMTA Alina-Andreea GULEI Diana SLABÝ Ondřej BERINDAN-NEAGOE Ioana

Year of publication 2019
Type Article in Periodical
Magazine / Source Journal of Clinical Medicine
MU Faculty or unit

Central European Institute of Technology

Citation
Web https://www.mdpi.com/2077-0383/8/12/2041/htm
Doi http://dx.doi.org/10.3390/jcm8122041
Keywords miR-21; head and neck cancer; survival; prognostic; bioinformatics analysis
Attached files
Description Head and neck squamous cell carcinoma (HNSCC) is a group of malignancies with serious impact on patient quality of life due to a reduced rate of response to chemotherapy or radiation therapy. MiR-21 has been identified as one of the most common proto-oncogenes. It is hypothesized that upregulated miR-21 could serve as a potential biomarker for human cancer diagnosis. Considering the target genes identified for miR-21 in HNSCC, this transcript is an important player in several cellular processes that control carcinogenesis. The abnormal expression of miR-21 in this group of pathologies has been assessed in several publications, but given the heterogeneity of the published results, a meta-analysis and proper bioinformatics analysis of expression databases are needed to correctly establish the prognostic potential of this molecule. The present meta-analysis comprises the published survival data on HNSCC patients, reported as HR and 95% CI, in association with the expression levels of miR-21. Our investigation revealed that miR-21 could be used successfully as a prognostic biomarker in HNSCC patients, confirming its oncogenic potential. Specifically, the upregulation of miR-21 in these patients predicts a worse outcome in terms of survival rate.
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