Inovativní klinické designy a personalizovaná medicína v dětské onkologii
| Title in English | Innovative clinical designs and personalized medicine in pediatric oncology |
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| Authors | |
| Year of publication | 2018 |
| MU Faculty or unit | |
| Citation | |
| Description | In the last decades of the last century, the fate of oncologically ill children has improved significantly and more than 80% of them have long-term remissions in developed countries. However, the first two decades of the new millennium have witnessed some stagnation in improving overall survival, and despite a better percentage of remissions achieved in a number of areas such as metastatic sarcomas, H3K27M mutated midline gliomas or some ependymomas, a significant percentage of patients are currently on treatment. inadequate, short-term or associated with very severe acute and long-term toxicity. |