Anti-alpha gal antibodies in the context of blood group and stool and tumour-adjacent microbiome in colorectal cancer patients

Warning

This publication doesn't include Faculty of Medicine. It includes Faculty of Science. Official publication website can be found on muni.cz.

Authors	SELINGEROVA I. BUDINSKÁ Eva ZWINSOVÁ Barbora MAZALOVA B. BENCSIKOVA B. VALIK D. DUBSKA L.Z.
Year of publication	2019
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	Gut microbiome plays a role in the development and clinical course of colorectal cancer (CRC). Natural antibodies against galactose-a-1,3-galactose (a-gal) are highly abundant in humans due to regular stimulation from gut bacteria. Similarly, Abs against AB0 blood group antigens are produced as cross-reacting with intestinal bacteria and a-gal epitope has similar structure to blood group B Ag. Blood group antigens may be associated with an expansion families of gut bacteria.