Léčba deprese u pacientů se schizofrenií
| Title in English | Treatment of depression in patients with schizophrenia |
|---|---|
| Authors | |
| Year of publication | 2020 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.cspsychiatr.cz/detail.php?stat=1331 |
| Keywords | schizophrenia; comorbid depression; second generation antipsychotics; adjunctive treatment |
| Description | Depressive symptoms occur frequently in patients with schizophrenia and may have far-reaching consequences. Suicidality is the most severe problem. Patients during the initial phase of the disease are particularly at high risk. There are obviously more etiopathogenetic mechanisms leading to development of depression in schizophrenia. Among treatment approaches at the first place a manipulation with antipsychotics (low-ering the dosage, switching antipsychotics); further, augmentation with antidepressants are recommended. We have limited data about other possibilities, for example augmentation with mood stabilizers. Non-pharmacological approaches such as stimulation methods seem to be promising. In patients with marked inflammatory markers an augmentation with anti-inflammatory agents might be successful. |