WNT5B in Physiology and Disease

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SUTHON Sarocha PERKINS Rachel S. BRYJA Vítězslav MIRANDA-CARBONI Gustavo A. KRUM Susan A.

Year of publication 2021
Type Article in Periodical
Magazine / Source Frontiers in Cell and Developmental Biology
MU Faculty or unit

Faculty of Science

Web https://www.frontiersin.org/articles/10.3389/fcell.2021.667581/full
Doi http://dx.doi.org/10.3389/fcell.2021.667581
Keywords WNT5B; WNT signaling; development; cancer; WNT5A
Description WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical beta-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high amino acid identity with WNT5A and is often assumed to have similar activities, WNT5B often exhibits unique expression patterns and functions. Here, we describe the distinct effects and mechanisms of WNT5B on development, bone, adipose tissue, cardiac tissue, the nervous system, the mammary gland, the lung and hematopoietic cells, compared to WNT5A. We also highlight aberrances in non-canonical WNT5B signaling contributing to diseases such as osteoarthritis, osteoporosis, obesity, type 2 diabetes mellitus, neuropathology, and chronic diseases associated with aging, as well as various cancers.
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