Laboratorní diagnostika imunitně podmíněných trombocytopenií

Title in English Laboratory testing of immune-mediated thrombocytopenias


Year of publication 2021
Type Article in Periodical
Magazine / Source Transfuze a hematologie dnes
MU Faculty or unit

Faculty of Medicine

Keywords HLA; HPA; Immune-mediated thrombocytopenia
Attached files
Description Immune-mediated thrombocytopenias are caused by alloantibodies or autoantibodies directed against platelet surface antigens. This group of immune disorders is divided into five types of thrombocytopenias in which platelet antibody testing is possible: immune thrombocytopenia, drug-induced immune thrombocytopenia, foetal and neonatal alloimmune thrombocytopenia, post-transfusion purpura, multi-platelet transfusion refractoriness. Laboratory testing involves detection and identification of patient serum antibodies using indirect tests or antibodies attached to patient platelets using direct tests. The analysis of blood samples for platelet antibody detection is complicated due to insufficient sensitivity of some laboratory tests. Identification of platelet-specific HPA antibodies provides important information, which facilitates the clinical diagnosis of immune-mediated disorder.

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