Association of the CD14 -260C/T polymorphism with plaque-induced gingivitis depends on the presence of Porphyromonas gingivalis
|Year of publication
|Article in Periodical
|Magazine / Source
|International Journal of Paediatric Dentistry
|MU Faculty or unit
|bacteria; CD14; gingivitis; polymorphism
|This study investigated the association between the functional polymorphism in the CD14 gene and the dental plaque microbiota in children with gingivitis.Gingivitis was detected in 64.2% of boys, but only in 35.8% of girls (P < .001). Children with gingivitis had a significantly higher occurrence of dental caries (P < .001). No significant differences in the CD14 -260C/T allele and genotype distribution among individuals with or without gingivitis in the whole cohort were found. Children with gingivitis and P gingivalis, however, were significantly more frequent carriers of the CT and TT genotypes than children with gingivitis without P gingivalis or healthy controls (P < .05).