Biliary obstruction in patients with gallbladder cancer: national registry-based analysis



Year of publication 2021
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Description Purpose: To compare efectiveness of plastic and metal stents insertion on survival in patients with gallbladder cancer. Materials and Methods: 3741 patients with diagnosis of gallbladder cancer between 2010-2018 were extracted from the databases of The Czech National Cancer Registry. The analysis was supported by data from the National Registry of Paid Health Services and the Death Records Database. 934 and 201 patients underwent plastic drain insertion and metal stent insertion, respectively. Patients treated with surgical procedure prior or after interventional procedure were analyzed separately. Overall survival after drain/stent insertion and disease diagnosis was assessed. Descriptive statistics and Kaplan-Maier analyses were used. Results: 577 patients with plastic drain insertion and 128 patients with metal stent insertion were enrolled for survival analyses. The survival after plastic drain and metal stent insertion was 2.7 months (95%CI 2.4-3.0) and 3.2 months (95%CI 2.6-3.7), respectively, p>0.05. The patients with inserted plastic drain followed by surgical treatment survived 3.2 - 15.1 months, patients treated only with plastic drain just 1.7 (95%CI 1.5-2.0) months. Insertion of plastic drain after surgery results in survival of 10.1 - 13.1 months. The metal stent insertion in patients without any additional treatment results in survival of 2.4 (95%CI 0.7-4.2) months. Conclusion: According to population-based data, the treatment of biliary obstruction in patients with unresectable gallbladder cancer with metal stent insertion is not accompanied with survival beneft compared to treatment with plastic drain. Data gathering from cancer register databases can provide further information on treatment efectiveness.
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