Možnosti sledování subpopulací B lymfocytů v periferní krvi v rutinní imunologické laboratoři
| Title in English | Possibilities for the analysis of peripheral blood B cell subpopulations in a routine immunological laboratory |
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| Authors | |
| Year of publication | 2021 |
| Type | Article in Periodical |
| Magazine / Source | Epidemiologie, mikrobiologie, imunologie |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.prolekare.cz/casopisy/epidemiologie/2021-4-24/moznosti-sledovani-subpopulaci-b-lymfocytu-v-periferni-krvi-v-rutinni-imunologicke-laboratori-129447 |
| Keywords | flow cytometry; B-cell; marginal zone of the spleen; germinal centre |
| Description | B cells play a vital role in the defence of the body against infectious agents. Apart from their ability to present antigen to T cells, B cells are mainly producers of antibodies. These play a crucial role in the effective elimination of infection and are also involved in the regulation of the immune response. The analysis of peripheral blood B cell subpopulations that makes it possible to monitor the development of B cells to the stage of antibody producing plasmablasts provides a valuable laboratory parameter which is important for both the study of the pathogenesis and diagnosis of some diseases. Laboratory analysis of B cell subpopulations is now a routinely available laboratory option thanks to the development of multicolour flow cytometry. This article summarizes the core knowledge which is currently applied to the analysis of B cell subpopulations in immunological laboratories. |