Hepatopatie indukovaná/asociovaná domácí parenterální výživou (PNALD, IFALD, PNAC)
| Title in English | Hepatopathy induced/associated home parenteral nutrition (PNAlD, IFAlD, PNAC) |
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| Authors | |
| Year of publication | 2022 |
| Type | Article in Periodical |
| Magazine / Source | Diabetologie Metabolismus Endokrinologie Výživa |
| Citation | |
| Keywords | home parenteral nutriton, intestinal failure, parenteral nutrition associated liver disease |
| Description | Home parenteral nutrition (HPN) is life saving therapy for patients with chronic intestinal failure caused by different etiology. Parenteral nutrition associated liver disease or intestinal failure associated liver disease (PNALD/IFALD) emcompasses a wide range of disease from steatosis, cholestasis, jaundice to end stage liver disease (ESLD). Diagnosis and monitoring of liver disease requires a complex of clinical, biochemical, radiological and where appropriate histology examination. It is important that other causes of derranged liver function are excluded before HPN. The management of PNALD/IFALD is based on multidisciplinary cooperation of nutritionist, hepatologist, radiologist and surgeron. ESLD with overt liver failure is an indication for small bowel and liver transplatation/multiviceral transplantation. Isolated small bowel transplantion is indicated for mild PNALD/IFALD cases. The purpose of this article is to discuss the current data dealing with IFALD prevention management and therapy. |