Destabilization of Ionic Transport Systems in Cardiomyocytes During Hypoxia and Ischemia
| Authors | |
|---|---|
| Year of publication | 2022 |
| Type | Article in Proceedings |
| Conference | Masaryk University Press |
| MU Faculty or unit | |
| Citation | |
| Web | https://is.muni.cz/do/med/noninvasive_methods_in_cardiology/Noninvasive_methods_in_cardiology_2022.pdf |
| Keywords | Ionic Transport Systems; Cardiomyocytes During Hypoxia and Ischemia |
| Description | In 1994, one hundred and thirty-six years after the introduction of the term “ischemia” by Virchow, the journal Cardiovascular Research conducted a survey among eminent cardiologists to find out “their” definition of myocardial ischemia (Hearse, 1994). The results showed the responses ranged from 3 to 404 words (!). This clearly shows that a generally accepted definition does not currently exist. However, it is undisputed that ischemia is necessarily associated with changes in the energy metabolism and ionic disturbances of the myocardium. It is difficult to study ischemia experimentally and in particular in isolated muscle preparations. For this reason, many studies concerning the effects of ischemia on contractile function have used experimental protocols that reproduce only some of the metabolic, ionic and mechanical aspects of ischemia. The most used models are hypoxia or anoxia, based on partial or total suppression of oxygen (O2 ) in the perfusion medium (replacement of O2 by nitrogen or application of a reducing agent, such as sodium dithionate), or even on the use of blockers of oxidative phosphorylation (OP) such as cyanide (CN). |