Způsob stanovení prognózy u pacientů s folikulárním lymfomem


This publication doesn't include Faculty of Medicine. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.
Title in English Method of prognosis in patients with follicular lymphoma


Year of publication 2023
Type Patent
MU Faculty or unit

Central European Institute of Technology

Publisher Úřad průmyslového vlastnictví
State Czech Republic
Patent's number 309489
Web Odkaz na PDF dokument v databázi ÚPV
Description The solution is a method of determining the prognosis of a patient suffering from follicular lymphoma by determining the amount of miR-31 in an isolated biological sample of the patient, and based on this determination, assigning the patient to a prognostic group, the prognostic groups and cut-off values for assigning to the prognostic groups are obtained by analyzing the amount of miR-31 in biological samples of patients with a known prognosis. In a biological sample taken from the patient's body, the expression of miR-31 can be determined together with the expression of an endogenous control, which is a small nuclear RNA or a stably expressed miRNA, and in the case of absolute quantification, the expression of synthetic standards of these miRNAs and endogenous controls of a known number of molecules. Determining prognosis does not include determining the transformation of follicular lymphoma into diffuse large B-cell lymphoma. The method can be used to assign patients to prognostic groups by determining the expression of miR-31.
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